Ali K. Hamou, Winter 2017,
"Basic Science to Clinical Research:
Segmentation of Ultrasound and Modelling in
Computer Science Department, University of
Western Ontario, Canada.
PhD. Thesis Abstract
The world of basic science is a world of minutia; it boils down to improving
even a fraction of a percent over the baseline standard. It is a domain of peer
reviewed fractions of seconds and the world of squeezing every last ounce of
efficiency from a processor, a storage medium, or an algorithm. The field of
health data is based on extracting knowledge from segments of data that may
improve some clinical process or practice guideline to improve the time and
quality of care. Clinical informatics and knowledge translation provide this
information in order to reveal insights to the world of improving patient
treatments, regimens, and overall outcomes.
In my world of minutia, or basic science, the movement of blood served an
integral role. The novel detection of sound reverberations map out the
landscape for my research. I have applied my algorithms to the various
anatomical structures of the heart and artery system. This serves as a basis
for segmentation, active contouring, and shape priors. The algorithms
presented, leverage novel applications in segmentation by using anatomical
features of the heart for shape priors and the integration of optical flow
models to improve tracking. The presented techniques show improvements over
traditional methods in the estimation of left ventricular size and function,
along with plaque estimation in the carotid artery.
In my clinical world of data understanding, I have endeavoured to decipher
trends in Alzheimer's disease, Sepsis of hospital patients, and the
of Melanoma using mathematical modelling methods. The use of decision trees,
Markov models, and various clustering techniques provide insights into data
sets that are otherwise hidden. Finally, I demonstrate how efficient data
capture from providers can achieve rapid results and actionable information on
patient medical records. This culminated in generating studies on the burden of
illness and their associated costs.
A selection of published works from my research in the world of basic sciences
to clinical informatics has been included in this thesis to detail my
transition. This is my journey from one contented realm to a turbulent one.