Ali K. Hamou and Mahmoud R. El-Sakka, "SRAD and Optical Flow 
                  Based External Energy for Echocardiograms with Shape Priors", 
                  IEEE International Conference on Image Processing, ICIP'2009, 
                  pp. 2613-2616, November 2009, Cairo, Egypt.
               
               
               
               Abstract
               
               
               
                  Accurate left ventricle border delineation is highly desirable
                  on inherently noisy clinical echocardiograms. Active contour
                  (or snake) is a powerful model-based image segmentation 
                  approach. In this work, we propose to use a modified gradient
                  vector flow (GVF) snake to segment noisy echocardiographic 
                  image cycles. The first modification is to use a speckle 
                  reducing anisotropic diffusion (SRAD) operator to reduce the 
                  inherent speckle noise within the image. The second 
                  modification is to utilize the movement of the vessels and 
                  tissues (identified by means of optical flow analysis) and
                  incorporate it into the external energy of the GVF snake. This
                  will provide the necessary structural information while 
                  ignoring static noise prone areas of the image cine. Finally,
                  the incorporation of an iterative priori knowledge process 
                  into the proposed solution will retract an expanding curve or 
                  correct a caving one when an expected border is occluded by 
                  noise. Results are compared with expert-defined segmentations
                  yielding better sensitivity, precision rate and overlap ratio 
                  than that of the standard GVF model.