Sherif Moursi and Mahmoud R. El-Sakka, "Semi-Automatic 
                  Snake-Based Segmentation of Carotid Artery Ultrasound Images",
                  Communications of the ACS Magazine, Vol. 2, No. 2 (32 pages),
                  December 2009.
               
               
               
               Abstract
               
               
               
                  Carotid ultrasound imaging is one of the clinical diagnostic 
                  procedures that can be employed to detect plaque buildup at 
                  the carotid artery walls. It is an inexpensive and 
                  non-invasive procedure that has no known side effects. Yet, 
                  the acquired ultrasound images have poor quality and contain
                  a lot of noise.
                  
                  
                  Active contouring segmentation techniques (also known as 
                  snakes or deformable model) are characterized by their 
                  robustness to both image noise and boundary gaps. Hence, they
                  are suitable to be used to segment noisy poor quality 
                  ultrasound images. One of the major issues of active 
                  contouring methods is their sensitivity to the initial contour
                  that is provided by the user. Unless it is drawn close enough
                  to the actual contour, it may lead to unsatisfactory results.
                  Thus, most active contour algorithms require considerable user
                  interaction to provide a good initial contour.
                  
                  
                  This paper presents an efficient algorithm for extracting 
                  carotid artery lumens in ultrasound images. It starts by 
                  utilizing a rule-based scheme to generate an initial contour
                  for the lumen. This contour is refined using a snake scheme, 
                  after carefully adjusting its energies. Our algorithm reduces 
                  the user interaction, as the user is only required to place a 
                  seed point inside the region of interest. It is worth 
                  mentioning that our proposed initial contour generation scheme
                  can be easily integrated as an independent module with any 
                  active contouring algorithm.
                  
                  
                  Sensitivity, precision rate, and overlap ratio are utilized to
                  assess the performance of the proposed scheme. The results 
                  show that the extracted initial and final contours have a good
                  overlap with contours that are manually segmented by an 
                  experienced clinician.